ハンセン病における血漿粘度の動態 The Involvement of Plasma Viscosity of Leprosy Patients in Southern China

この論文にアクセスする

この論文をさがす

著者

    • 王 黎曼 WANG Li-man
    • 東京医科歯科大学・難治疾患研究所・予防医学 Department of Preventive Medicine, Medical Research Institute, Tokyo Medical and Dental University
    • 本田 由美子 [他] HONDA Yumiko
    • 東京医科歯科大学・難治疾患研究所・予防医学 Department of Preventive Medicine, Medical Research Institute, Tokyo Medical and Dental University
    • 峰下 哲 MINESHITA Satoru
    • 東京医科歯科大学・難治疾患研究所・予防医学 Department of Preventive Medicine, Medical Research Institute, Tokyo Medical and Dental University

抄録

To investigate the effects of plasma viscosity to leprosy patients in Southern China, we measured plasma viscosity, plasma fibrinogen and total-cholesterol in 71 patients, with a mean age of 63±27.3 years (range, 22 to 84 years), and the duration of their disease varied from 8 to 69 years. Fifty-one patients had multibacillary leprosy (MB) and 20 had paucibacillary leprosy (PB), according to the diagnostic criteria of World Health Organization-recommended multidrug therapy (WHO-MDT). Plasma viscosity was determined using Low Shear 40 (LS40, Contraves, Switzerland). The shear rate was 0-50 (1/s), temperature was 37±1°C. Plasma fibrinogen and total-cholesterol were determined using the fibrinogen kit (Coagrex, International Reagents Corporation, Japan) and Vision pack (Dainabot, Japan). We found plasma viscosity was in high level in the patients with older age of years, and plasma viscosity was remarkably increased in the leprosy patients (1.54±0.17mPa·s), compared with that of healthy volunteers (1.44±0.06mPa·s, P <0.01). Plasma fibrinogen level was396.6±121.4mg/d1, and total-cholesterol level was 143.3±41.8 mg /dl, these levels were higher than those of healthy volunteers (315.6±97.4 md/dl, 131.8±33.4 mg/dl,respectively). These results suggest the plasma fibrinogen level correlates closely with plasma viscosity and the involvement of plasma viscosity plays an important role in the pathogenesis of leprosy as seen in other infectious diseases.

収録刊行物

  • 日本バイオレオロジー学会誌(B&R) = Journal of Japanese Society of Biorheology  

    日本バイオレオロジー学会誌(B&R) = Journal of Japanese Society of Biorheology 14(2), 62-68, 1999-07-29 

    特定非営利活動法人 日本バイオレオロジー学会

参考文献:  15件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10004712704
  • NII書誌ID(NCID)
    AN10042423
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    09134778
  • NDL 記事登録ID
    5465351
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z18-1996
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ