赤血球浮遊安定性への静水圧の影響 Effect of hydrostatic pressure on stability of erythrocyte suspension

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著者

    • 外山 吉治 TOYAMA Y.
    • 群馬大学工学部生物化学工学科 Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University
    • 大川 信ニ OHKAWA S.
    • 群馬大学工学部生物化学工学科 Department of Biological and Chemical Engineering, Faculty of Engineering, Gumna University
    • 蛭間 敬 HIRUMA K.
    • 群馬大学工学部生物化学工学科 Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University
    • 彼谷 美千子 KAYA M.
    • 群馬大学工学部生物化学工学科 Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University
    • 坂西 明郎 SAKANISHI A.
    • 群馬大学工学部生物化学工学科 Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University

抄録

There have been many reports about the temperature effects on the stability of erythrocyte suspension. On the other hand, pressure together with temperature is an important parameter for the study of this phenomenon. In this study, we have measured erythrocyte sedimentation rate (<I>ESR</I>) under high pressure up to 200 MPa. The <I>ESR</I> in autologous plasma increased with increasing pressure up to 80 MPa and then decreased. Above 160 MPa, the <I>ESR</I> were lower than that at atmospheric pressure. Application of pressure higher than 160 MPa induced the shape change of erythrocytes and their aggregates. The erythrocytes transformed into spherocytes, and aggregates changed in shape from rouleaux to three-dimensional aggregates. These results were discussed from alterations of physicochemical properties, both of the erythrocyte membrane and plasma proteins, under high pressure.

収録刊行物

  • 日本バイオレオロジー学会誌(B&R) = Journal of Japanese Society of Biorheology  

    日本バイオレオロジー学会誌(B&R) = Journal of Japanese Society of Biorheology 14(2), 69-74, 1999-07-29 

    特定非営利活動法人 日本バイオレオロジー学会

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各種コード

  • NII論文ID(NAID)
    10004712720
  • NII書誌ID(NCID)
    AN10042423
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    09134778
  • NDL 記事登録ID
    5465363
  • NDL 雑誌分類
    ZR2(科学技術--生物学--生化学)
  • NDL 請求記号
    Z18-1996
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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