Partial Least Squaresと赤外分光法による生化学成分の同時センシング Simultaneous Analyses of BioChemical Components in Blood Using Infrared Spectroscopy Combined with Partial Least Squares

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Simultaneous quantitative analyses of biochemical substances were carried out using attenuated total reflection and Fourier transform infrared spectroscopy (ATR/FT-IR) combined with partial least squares. The concentrations of glucose, cholesterol, and triglycerides in human serum were measured simultaneously using the low-temperature ATR/FT-IR. The infrared absorption band of proteins in human serum measured at -2.4°C increased 5 times as large as that measured at room temperature. The increase was based on segregation of biochemical components during solidification process. The correlation coefficients between the concentrations determined by the low-temperature ATR/FT-IR and those determined by the conventional method were over 0.86. The fundamental investigation of simultaneous analysis of two enzymes, amylase and creatine kinase, was performed using ATR/FT-IR at room temperature. The changes in the concentrations of the products specific to the enzymes were measured simultaneously. The correlation coefficients between the concentrations of the products and the enzyme activities were over 0.95. The ATR/FT-IR combined with chemometrics would be a useful technique for a biochemical sensing system with a short turn-around time and easy maintenance.

収録刊行物

  • 電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society  

    電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society 117(6), 332-337, 1997-06 

    The Institute of Electrical Engineers of Japan

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各種コード

  • NII論文ID(NAID)
    10004832229
  • NII書誌ID(NCID)
    AN1052634X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    13418939
  • NDL 記事登録ID
    4216685
  • NDL 雑誌分類
    ZN31(科学技術--電気工学・電気機械工業)
  • NDL 請求記号
    Z16-B380
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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