Immobilization of Biomaterial by Random Fluidic Self-Assembly Method

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  • Random fluidic self-assembly法による生体材料の固定化
  • ホウ ニ ヨル セイタイ ザイリョウ ノ コテイカ

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Abstract

We propose a novel method for individual immobilization of biomaterial for biosensor application. Various kinds of biomaterial were first immobilized on certain supports such as glass beads or microfabricated metal particles of which size is almost the same as the size of transducer element. Then the suspension mixture of the various support was arranged on the transducer array by the fluidic self-assembly method at random. Glass beads immobilized with glucose oxidase and/or peroxidase were successfully arranged by this method using gravity, as a short-range force required in self-assembly. The beads gave chemiluminescence with the addition of luminol and its substrate. The metal particles consisted of nickel and/or gold layers formed by electroplating and evaporation on a photolithographically patterned chip. The coin-shaped particles were arranged on a nickel dot array by magnetic force interaction as the short-range force. The direction of binding of the particles were also controllable using the multilayer structure.

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