Amplification of SPR Responses for the Immunoreaction using Anti HIV gp41 Antibody by the Method of Molecular Accumulation (特集 バイオセンサ) Amplification of SPR responses for the immunoreaction using anti HIV gp41 antibody by the method of molecular accumulation

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Improvement of the detection limit of surface plasmon resonance (SPR) apparatus is an important issue when it is applied to immunosensor to detect the biological substances in serum and/or urine. In this study, we investigated two kinds of molecular accumulation methods. The method of consecutive accumulation, in which the second and third antibodies were successively bound onto the antigen (gp41 of human immunodeficiency virus-1), enhanced the SPR response to the anti gp41 antibody binding by about 7 fold. On the other hand, the method of complexed antibody accumulation, in which the second and third antibodies were simultaneously bound onto the antigen, gave the higher response by over 10 fold. In these methods, the appropriate second and third antibodies must be chosen in addition to determination of the preferable concentration.

収録刊行物

  • 電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society  

    電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society 119(11), 522-527, 1999-11 

    The Institute of Electrical Engineers of Japan

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各種コード

  • NII論文ID(NAID)
    10004834443
  • NII書誌ID(NCID)
    AN1052634X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    13418939
  • NDL 記事登録ID
    4892670
  • NDL 雑誌分類
    ZN31(科学技術--電気工学・電気機械工業)
  • NDL 請求記号
    Z16-B380
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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