Effects of Bitter Antibiotics on Electrical Potential Oscillation across a Water/Octanol/Water Liquid Membrane (特集 バイオセンサ) Effects of Bitter Antibiotics on Electrical Potential Oscillation across a Water/Octanol/Water Liquid Membrane

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Electrical potential oscillation across an octanol membrane consisting of octanol solution containing 5mM tetrabutylammonium chloride between aqueous solution of 1% ethanol and aqueous solution of 8mM sodium dodecyl sulfate and 5M ethanol was measured in the presence of antibiotics. Comparison was made of the mode of potential oscillation in response to antibiotic aqueous solution taste. Four antibiotics, erythromycin, chloramphenicol, ampicillin and cefpodoxime proxetil served as the antibiotics. All antibiotics caused the lower potential of the first pulse, <i>E</i><sub>L</sub>, to shift to more positive values with increase in concentration. Potential immediately after solution contact, <i>E</i><sub>_??_</sub>, and potential prior to the start of oscillation, <i>E</i><sub>H</sub>, showed virtually no dependence on concentration. The bitterness of aqueous solution antibiotics was assessed by 8 volunteers (males and females, aged 21-25). For the same antibiotic, <i>E</i><sub>L</sub> increased with bitterness scores. Potential oscillation would thus appear to depend on the degree of bitterness of the same antibiotic. Change in the mode of oscillation according to cefpodoxime proxetil and <i>simple syrup</i> (2.5M sucrose solution, as flavoring agent prescribed by the Japanese Pharmacopoeia) was examined. The oscillation mode for cefpodoxime proxetil corresponded to that due to bitter substances, as previously noted, and cefpodoxime proxetil with 10% simple syrup, sweet substances. The oscillation may reflect the taste of an antibiotic solution, which may be assessed using the octanol membrane.

収録刊行物

  • 電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society  

    電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society 119(11), 544-548, 1999-11 

    The Institute of Electrical Engineers of Japan

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各種コード

  • NII論文ID(NAID)
    10004834511
  • NII書誌ID(NCID)
    AN1052634X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    13418939
  • NDL 記事登録ID
    4892703
  • NDL 雑誌分類
    ZN31(科学技術--電気工学・電気機械工業)
  • NDL 請求記号
    Z16-B380
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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