Effects of Bitter Antibiotics on Electrical Potential Oscillation across a Water/Octanol/Water Liquid Membrane

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Electrical potential oscillation across an octanol membrane consisting of octanol solution containing 5mM tetrabutylammonium chloride between aqueous solution of 1% ethanol and aqueous solution of 8mM sodium dodecyl sulfate and 5M ethanol was measured in the presence of antibiotics. Comparison was made of the mode of potential oscillation in response to antibiotic aqueous solution taste. Four antibiotics, erythromycin, chloramphenicol, ampicillin and cefpodoxime proxetil served as the antibiotics. All antibiotics caused the lower potential of the first pulse, EL, to shift to more positive values with increase in concentration. Potential immediately after solution contact, E_??_, and potential prior to the start of oscillation, EH, showed virtually no dependence on concentration. The bitterness of aqueous solution antibiotics was assessed by 8 volunteers (males and females, aged 21-25). For the same antibiotic, EL increased with bitterness scores. Potential oscillation would thus appear to depend on the degree of bitterness of the same antibiotic. Change in the mode of oscillation according to cefpodoxime proxetil and simple syrup (2.5M sucrose solution, as flavoring agent prescribed by the Japanese Pharmacopoeia) was examined. The oscillation mode for cefpodoxime proxetil corresponded to that due to bitter substances, as previously noted, and cefpodoxime proxetil with 10% simple syrup, sweet substances. The oscillation may reflect the taste of an antibiotic solution, which may be assessed using the octanol membrane.

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