Glucose Sensor Based on Nickelocene Blended Carbon Paste Electrode

• Toyama Shigeru

  National Rehabilitation Center for the Disabled

• Chisuwa Yukinao

  Toyo University

• Ikariyama Yoshihito

  National Rehabilitation Center for the Disabled

Bibliographic Information

Other Title

• Glucose Sensor Based on Nickelocene Blended Carbon Paste Electrode--Suppression of Enzyme Leaking from Electrode Surface
• Suppression of Enzyme Leaking from Electrode Surface

Abstract

An amperometric glucose sensor based on carbon paste electrode containing glucose oxidase, nickelocene, and platinum particles was fabricated and characterized. The sensor was functional at a less extreme potential (-200 mV vs. Ag/AgCl) than those of amperometric mediator free sensors. The sensor worked not only in buffer solution but in serum. The output current was unaffected by ascorbate, whose concentration was about two orders of magnitude above the standard ascorbate concentration in human blood. Although the sensor response decreased gradually when native-enzyme was coblended, the sensor in which the enzyme was modified with methoxy-polyethylene-glycol-epoxy was much stabler due to the suppression of enzyme leakage than that with native-enzyme coblended.

Journal

• IEEJ Transactions on Sensors and Micromachines

  IEEJ Transactions on Sensors and Micromachines 119 (11), 560-564, 1999

  The Institute of Electrical Engineers of Japan

Keywords

• glucose sensor
• less extreme potential
• nickelocene
• polyethylene glycol
• PEG-modification

Details

• CRID: 1390282679439321216
• NII Article ID: 10004834567
• NII Book ID: AN1052634X
• DOI: 10.1541/ieejsmas.119.560
• ISSN: 13475525
• ISSN: 13418939
• NDL BIB ID: 4892759
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4892759
• Web Site: http://www.jstage.jst.go.jp/article/ieejsmas1995/119/11/119_11_560/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed