DNA固定化カーボンフェルトをリアクターとするDNA結合性薬物のフロー型バイオセンシング Flow-through Biosensing of DNA-binding Drugs using DNA-Immobilized Carbon Felt as a Reactor

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Oxygen electrode-based flow-type amperometric mutant sensor was proposed using DNA-immobilized carbon felt as a sensing element for DNA-binding drugs. Catalytic activity of immobilized DNA-Cu (II) complex for air oxidation of aminoethanthiol (AET) was reversibly inhibited by intercalation with DNA binding drugs and antibiotics. Kinetic measurements indicate that quinacrine (QN) competitively inhibits the DNA-Cu (II) complex-catalyzed oxidation of AET. These phenomena could be utilized for development of novel flow-type biosensing system for DNA-binding drugs consisting with immobilized DNA-Cu (II) reactor and oxygen electrode detector. The peak-shape current responses were observed for various DNA-binding drugs, and the magnitude and the shape of the responses depend considerably on the kinds and concentrations of DNA-binding drugs.

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  • 電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society  

    電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society 119(11), 571-575, 1999-11 

    The Institute of Electrical Engineers of Japan

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各種コード

  • NII論文ID(NAID)
    10004834592
  • NII書誌ID(NCID)
    AN1052634X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    13418939
  • NDL 記事登録ID
    4892807
  • NDL 雑誌分類
    ZN31(科学技術--電気工学・電気機械工業)
  • NDL 請求記号
    Z16-B380
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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