ポルフィラン由来オリゴ糖の消化・発酵性とマウスの血清コレステロール低下作用 Effect of Oligosaccharides from Porphyran on In Vitro Digestions, Utilizations by Various Intestinal Bacteria, and Levels of Serum Lipid in Mice
Digestion of porphyran by enzymes of <i>Arthrobacter</i> sp. S-22 caused neoagarotetraose (NOSP) fraction, sulphated oligosaccharide (DP≤6) (OSP3) fraction, sulphated tetrasaccharide (OSP2) fraction, and sulphated disaccharide (OSP1) fraction. Purified NOSP, OSP2 and OSP1 were partially digested <i>in vitro</i> by α-amylase from human saliva and rat intestinal acetone powder. No digestions were observed <i>in vitro</i> using artificial gastric juice and porcine pancreas. Neoagarotetraose was utilized <i>in vitro</i> by intestinal bacteria, <i>Bacteroides</i>. Hypocholesteromic activities in mice were found in porphyran and all oligosaccharide fractions tested (NOSP, OSP3, OSP2, and OSP1). The percentage of totalserum cholesterol fed with OSP2 and OSP1 were 72 and 67%, respectively, to that of the control.
日本水産学会誌 64(1), 98-104, 1998-01-15