Formation of intermediate conjugates in the reductive transformation of gonyautoxins to saxitoxins by thiol compounds.

• SAKAMOTO SETSUKO

  School of Fisheries Sciences, Kitasato University

• SATO SHIGERU

  School of Fisheries Sciences, Kitasato University

• OGATA TAKEHIKO

  School of Fisheries Sciences, Kitasato University

• KODAMA MASAAKI

  School of Fisheries Sciences, Kitasato University

Abstract

The activity of bacterial extracts to transform gonyautoxins to saxitoxins was found to be due to glutathione. This activity was also found in another thiol compound, 2-mercaptoethanol. These thiol compounds did not reduce 1-N-OH of gonyautoxin 1 and 4. Interestingly, the stable intermediate conjugates of paralytic shellfish toxins and thiol compounds were formed in the course of the reaction, which demonstrates that this is a two-step reaction consisting of formation of intermediate and degradation of the intermediate to saxitoxins.

Journal

• Fisheries science

  Fisheries science 66 (1), 136-141, 2000

  The Japanese Society of Fisheries Science

Keywords

• 2-mercaptoethanol
• conjugate
• glutathione
• gonyautoxin
• intermediate
• paralytic shellfish toxin
• saxitoxin
• thiol compound

Details

• CRID: 1390282679406773888
• NII Article ID: 130003903458
• NII Article ID: 10004857483
• NII Book ID: AA10993718
• DOI: 10.1046/j.1444-2906.2000.00020.x
• ISSN: 14442906
• ISSN: 09199268
• NDL BIB ID: 5297004
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5297004
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed