Effect of Drug-metabolizing Enzyme Activity Induced by PCB on the Residence Time of Oxolinic Acid, Piromidic Acid and Nalidixic Acid in Carp

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A study was made of the effect of drug-metabolizing enzyme activity induced by polychlorinated biphenyl (PCB) on the residence time of quinoline antibacterial agents in carp Cyprinus carpio. Carp were fed with a diet containing PCB (1mg PCB/kg body weight/day) for 2 weeks toinduce drugmetabolizing enzymes. After pretreatment, three kinds of quinoline antibacterialagents (oxolinic acid, piromidic acid and nalidixic acid) were individually administered in feed to PCB-treated or nontreated (as control) fish as a single dose of 20mg/ kg body weight. The peak concentrations of oxolinic acid in the blood, liver and muscle of PCB-treated fish were lower than half of those inthe control. The concentrations of piromidic acid in the liver, muscle and kidney of PCB-treated fish were undetectable throughout the experiment (2 to 98 h post dosing), except in the blood. However, the residence time and concentration of nalidixic acid in the tissues of PCB-treated fish showed nosignificant difference comnared with those in the control.

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  • Fisheries science : FS  

    Fisheries science : FS 62(2), 302-306, 1996 

    公益社団法人 日本水産学会

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各種コード

  • NII論文ID(NAID)
    10004865741
  • NII書誌ID(NCID)
    AA10993718
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09199268
  • NDL 記事登録ID
    3951209
  • NDL 雑誌分類
    ZR26(科学技術--農林水産--水産)
  • NDL 請求記号
    Z54-H592
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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