Effect of Drug-metabolizing Enzyme Activity Induced by PCB on the Residence Teme of Oxolinic Acid, Piromidic Acid and Nalixic Acid in Carp
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- Oshima Yuji
- Department of Fisheries, Faculty of Agriculture, Kyushu University
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- Fachrudin Liestiaty
- Department of Fishery, Faculty of Animal Husbandry, Hasanuddin University
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- Ishida Noriko
- National Research Institute of Fisheries Science
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- Imada Nobuyoshi
- Department of Fisheries, Faculty of Agriculture, Kyushu University
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- Kobayashi Kunio
- Department of Fisheries, Faculty of Agriculture, Kyushu University
Bibliographic Information
- Other Title
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- Effect of Drug-metabolizing Enzyme Activity Induced by PCB on the Residence Time of Oxolinic Acid,Piromidic Acid and Nalidixic Acid in Carp
- Effect of Drug metabolizing Enzyme Acti
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Abstract
A study was made of the effect of drug-metabolizing enzyme activity induced by polychlorinated biphenyl (PCB) on the residence time of quinoline antibacterial agents in carp Cyprinus carpio. Carp were fed with a diet containing PCB (1mg PCB/kg body weight/day) for 2 weeks toinduce drugmetabolizing enzymes. After pretreatment, three kinds of quinoline antibacterialagents (oxolinic acid, piromidic acid and nalidixic acid) were individually administered in feed to PCB-treated or nontreated (as control) fish as a single dose of 20mg/ kg body weight. The peak concentrations of oxolinic acid in the blood, liver and muscle of PCB-treated fish were lower than half of those inthe control. The concentrations of piromidic acid in the liver, muscle and kidney of PCB-treated fish were undetectable throughout the experiment (2 to 98 h post dosing), except in the blood. However, the residence time and concentration of nalidixic acid in the tissues of PCB-treated fish showed nosignificant difference comnared with those in the control.
Journal
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- Fisheries science
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Fisheries science 62 (2), 302-306, 1996
The Japanese Society of Fisheries Science
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Details 詳細情報について
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- CRID
- 1390282679404669184
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- NII Article ID
- 10004865741
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- NII Book ID
- AA10993718
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- NDL BIB ID
- 3951209
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- ISSN
- 09199268
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed