Studies on Tobicillin, a New Antibiotic Drug for Enterococcicosis in Yellowtail <i>Seriola quinqueradiata</i>
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- Ooshima Takeo
- Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- Kaneda Shigeo
- Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- Ise Naomi
- Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- Okada Masaaki
- Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- Takagi Hirofumi
- Chemical Products Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Bibliographic Information
- Other Title
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- Studies on Tobicillin,a New Antibiotic Drug for Enterococcicosis in Yellowtail Seriola quinqueradiata
- Studies on Tobicillin a New Antibiotic
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Abstract
Tobicillin (TBPC), an ester derivative of penicillin G (PCG), was examined as a treatment for enterococcicosis in yellowtail.<br> After 6h at 25°C at pH 3, the residual rate of TBPC was over 80%, but that of PCG was only 20%. TBPC was stable in an acidic solution (pH 3).<br> The area under the blood concentration-time curve (AUC) between 0 and 10h afteroral administration was about 7 times higher for TBPC (35.2 μg/ml•h) than that for PCG (5.2 μg/ml•h).<br> In drug sensitivity tests using 156 strains of field-isolated Enterococcus seriolicida, the MICs of PCG were 0.39-0.78 μg/ml, and no strains were resistant to PCG. On the other hand, the MICs of erythromycin, lincomycin and oxytetracycline showed biphasic distributions that included both resistant and sensitive strains.<br> In a preliminary evaluation of the efficacy of TBPC against experimental enterococcicosis in yellowtail, the cumulative death rate 5 days after infection was 56% for the non-treated group and 0% for the group treated with 100mg (potency)/kg/day.<br> These results indicate that TBPC will be one of the effective antibiotics for the treatment of enterococcicosis in yellowtail.
Journal
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- Fisheries science
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Fisheries science 63 (5), 741-745, 1997
The Japanese Society of Fisheries Science
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Details 詳細情報について
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- CRID
- 1390282679407029376
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- NII Article ID
- 130003903105
- 10004871504
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- NII Book ID
- AA10993718
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- NDL BIB ID
- 4326627
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- ISSN
- 09199268
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed