Inhibitory Potencies of Bromophenols from Rhodomelaceae Algae against α-Glucosidase Activity

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Inhibitory potencies against α-glucosidase activities were compared among bromophenols obtained from extracts of three Rhodomelaceae red algae, Symphyocladia latiuscula, Odonthalia corymbifera, and Polysiphonia morrowii. The bromophenols from these species are characterized by a number of Br atoms per benzene ring: S. latiuscula, three Br atoms (1 and 2); O. corymbifera, two Br atoms (3-7); and P. morrowii, one Br atom (8 and 9). The bromophenols exhibited mixed inhibition against yeast α-glucosidase reaction. In particular, symmetric dibenzyl ethers, bis(2,3,6-tribromo-4,5-dihydroxybenzyl) ether (2) and bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (5), exhibited about 10^3 fold smaller K_i values than the other bromophenols. Their inhibition modes are disclosed to be mixed inhibition closed to competitive inhibition. Inhibitory potencies of the bromophenols increased with the increasing degree of bromo-substitution per benzene ring and the decreasing degree of methyl-substitution. In contrast to the strong inhibitory activity against yeast α-glucosidase activity, the bromophenols moderately inhibited rat-intestinal sucrase and maltase activity. The inhibitory potencies were all comparative among the bromophenols examined.

収録刊行物

  • Fisheries science : FS

    Fisheries science : FS 65(2), 300-303, 1999

    Japanese Society of Fisheries Science

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各種コード

  • NII論文ID(NAID)
    10004878523
  • NII書誌ID(NCID)
    AA10993718
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09199268
  • NDL 記事登録ID
    4706598
  • NDL 雑誌分類
    ZR26(科学技術--農林水産--水産)
  • NDL 請求記号
    Z54-H592
  • データ提供元
    CJP書誌  NDL  IR 
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