Acid Treatment Increased Leukotriene B₄ in The Red Alga, <i>Gracilaria asiatica</i> (=<i>verrucosa</i>)

• Sajiki Junko

  The Public Health Laboratory of Chiba Prefecture

Bibliographic Information

Other Title

• Acid Treatment Increased Leukotriene B4 in The Red Alga,Gracilaria asiatica(=verrucosa)

Abstract

The effects of heat and acid treatments on eicosanoids concentration in the red alga, Gracilaria asiatica, were investigated. Leukotriene B₄ (LTB₄) and prostaglandin A₂ (PGA₂) increased but PGE₂ decreased when the alga was boiled with 4% acetic acid. Two isomers of LTB₄, which appeared in the HPLC of both the authentic LTB₄ and the extract of alga treated with acid, were identified as 6-trans-LTB₄ and 6-trans-12-epi-LTB₄. The concentration of LTB₄ increased when the alga was added with 4% acetic acid after boiling and incubated at 37°C at pH2 (pH similar to gastric fluid). Furthermore, the alga extract showed similar chemotactic activity to mice polymorphonuclear leukocytes as the authentic LTB₄. Mice orally administered with the algal extract containing 50μg of LTB₄ showed diarrhea, but it did not result in death.

Journal

• Fisheries science

  Fisheries science 65 (6), 914-918, 1999

  The Japanese Society of Fisheries Science

Keywords

• Red alga
• <i>Gracilaria asiatica</i> (=<i>verrucosa</i>)
• Leukotriene B₄
• Acid treatment
• Chemotactic activity

Details

• CRID: 1390282679404923904
• NII Article ID: 130003903406
• NII Article ID: 10004881331
• NII Book ID: AA10993718
• DOI: 10.2331/fishsci.65.914
• NDL BIB ID: 4944261
• ISSN: 09199268
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4944261
• Web Site: https://www.jstage.jst.go.jp/article/fishsci1994/65/6/65_6_914/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed