Decline in the HIV-1 Isolation Rate in Japan:A 12-Year Observation

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著者

    • NAGANAWA Satoshi
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • SOMEYA Kenji
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • YOSHINO Naoto
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • KAIZU Masahiko
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • OHSU Takeaki
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • TAKIZAWA Mari
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • IZUMI Yasuyuki
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • KAWAHARA Mamoru
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • HARA Takashi
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • FUJIMURA Yoshihiro
    • Department of Blood Transfusion Service and Second Department of Internal Medicine, Nara Medical University
    • YAMADA Kaneo
    • Institute of Medical Sciences, St.Marianna University of Medicine
    • NAGAI Yoshiyuki
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • YAMAZAKI Shudo
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases
    • HONDA Mitsuo
    • Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases

抄録

Since 1988, we have isolated HIV-1 from 614 HIV-1-infected persons (total sample=2, 785) in Japan. During the past 12 years, we have found a decline in the HIY-1 isolation rate in Japan, with two identifiable turning points, 1991-1992 and 1996-1997. The two turning points correspond to shifts in anti-HIV-1 therapy. These findings suggest that HIV-1 in Japan is currently biologically well controlled, probably due to anti-HIV-1 therapy. On the other hand, this decline is inconsistent with the recent increase of genetic drug-resistant HIV-1 in Japan. Further studies are needed to clarify mechanisms that might explain the discrepancy.

収録刊行物

  • Microbiology and immunology  

    Microbiology and immunology 44(11), 949-952, 2000-11-20 

    Center For Academic Publications Japan

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キーワード

各種コード

  • NII論文ID(NAID)
    10004892626
  • NII書誌ID(NCID)
    AA00738350
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    03855600
  • NDL 記事登録ID
    5561266
  • NDL 雑誌分類
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL 請求記号
    Z53-M387
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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