Reduced Anti-Pseudomonas aeruginosa Activity of a Cephalosporin, Cefodizime, in Rats Whose Neutrophils Were Selectively Depleted by a Monoclonal Antibody

  • ARAKI Akemi
    Department of Immunology and Parasitology, Yamagata University School of Medicine
  • SENDO Fujiro
    Department of Immunology and Parasitology, Yamagata University School of Medicine

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Abstract

In order to clarify the mechanisms of the in vivo antibacterial activity of a cephalosporin, cefodizime (CDZM), the effect of this antibiotic on Pseudomonas aeruginosa E7 infection was examined in rats whose neutrophils had been selectively depleted by monoclonal antibody RP-3. CDZM was less effective in RP-3-treated rats than in untreated rats. However, treatment of rats with recombinant human granulocyte-colony stimulating factor (rhG-CSF) augmented the in vivo activity of this antibiotic. Furthermore, the in vivo antibacterial activity of two other cephalosporins, cefpimizole (CPIZ) and cefoperazone (CPZ), was bilaterally affected by a rise or fall in the neutrophil number, although to a lesser degree than was the case with CDZM. Taken together, neutrophils play an important role in the in vivo antibacterial activity of certain cephalosporins.

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