Involvement of Two Types of TNF Receptor in TNF-α Induced Neutrophil Apoptosis

• GON Songi

  Department of Immunology and Parasitology, Yamagata University School of Medicine

• GATANAGA Tetsuya

  Department of Molecular Biology and Biochemistry, University of California

• SENDO Fujiro

  Department of Immunology and Parasitology, Yamagata University School of Medicine

抄録

We previously demonstrated that tumor necrosis factor-α (TNF-α) induces rapid human neutrophil apoptosis. In this paper, we examined which of the TNF receptors, p55kDa TNF receptor (55-R) or p75kDa TNF receptor (75-R), or both are involved in this process using specific rabbit antisera. Antibodies to 55-R (anti55-R) or 75-R (anti75-R) alone did not induce neutrophil apoptosis. Further addition of cycloheximide and anti-rabbit immunoglobulin to anti55-R but not to anti75-R accelerated apoptosis, although anti75-R augmented the capacity of anti55-R to do so. These results suggest that 55-R is a prerequisite for TNF-α induced neutrophil apoptosis.

収録刊行物

• Microbiology and immunology

  Microbiology and immunology 40 (6), 463-465, 1996-06-20

  財団法人 学会誌刊行センター

キーワード

• TNF-α
• TNF receptor
• Apoptosis
• Neutrophil

詳細情報

• CRID: 1572824499115187328
• NII論文ID: 10004893194
• NII書誌ID: AA00738350
• ISSN: 03855600
• Web Site: http://chemport.cas.org/cgi-bin/sdcgi?APP=ftslink&action=reflink&origin=jstage2&version=1.0&coi=1:CAS:528:DyaK28Xkt1Cms7g%3D&md5=3061798aed295c508f6212546ccfd9a1
• Web Site: https://search.jamas.or.jp/link/ui/1997042839
• 本文言語コード: en
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