Effect of Macrolide Antibiotics on Macrophage Functions

• XU Guang

  First Department of Internal Medicine, Kagawa Medical School

• FUJITA Jiro

  First Department of Internal Medicine, Kagawa Medical School

• NEGAYAMA Kiyoshi

  Clinical Laboratory, Kagawa Medical School

• YUUBE Koichi

  Equipment Center, Kagawa Medical School

• HOJO Satoko

  First Department of Internal Medicine, Kagawa Medical School

• YAMAJI Yasufumi

  First Department of Internal Medicine, Kagawa Medical School

• KAWANISHI Koichi

  Clinical Laboratory, Kagawa Medical School

• TAKAHARA Jiro

  First Department of Internal Medicine, Kagawa Medical School

抄録

Macrolide antibiotics have a variety of actions other than antimicrobial activities. Recently, it has been suggested that macrolide antibiotics act as immunomodulators. In this study, we evaluated the effects of macrolide antibiotics on macrophage functions. For the macrophage, we used the mouse macrophage cell line J774.1. The following effects of macrolide antibiotics on macrophage functions were evaluated: the effect of macrolide antibiotics on macrophage growth; the phagocytosis of beads; cytocidal activity against Candida albicans; and chemotaxis to lipopolysaccharide (LPS). Macrolide antibiotics except for azithromycin significantly stimulated the growth of the macrophage. In addition, pretreatment with macrolide antibiotics except for roxithromycin significantly stimulated the macrophage phagocytosis of beads, macrophage chemotaxis to LPS, and macrophage cytocidal activity against Candida albicans. These results suggest that macrolide antibiotics stimulate macrophage functions.

収録刊行物

• Microbiology and immunology

  Microbiology and immunology 40 (7), 473-479, 1996-07-20

  財団法人 学会誌刊行センター

キーワード

• Macrolide antibiotics
• Macrophage functions
• Immunomodulator

詳細情報

• CRID: 1571417124231427584
• NII論文ID: 10004893233
• NII書誌ID: AA00738350
• ISSN: 03855600
• Web Site: http://chemport.cas.org/cgi-bin/sdcgi?APP=ftslink&action=reflink&origin=jstage2&version=1.0&coi=1:CAS:528:DyaK28XltVOgsr4%3D&md5=9535a19001b4b59da35f6466af1bb661
• Web Site: https://search.jamas.or.jp/link/ui/1997048757
• 本文言語コード: en
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