Effect of Macrolide Antibiotics on Macrophage Functions
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- XU Guang
- First Department of Internal Medicine, Kagawa Medical School
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- FUJITA Jiro
- First Department of Internal Medicine, Kagawa Medical School
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- NEGAYAMA Kiyoshi
- Clinical Laboratory, Kagawa Medical School
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- YUUBE Koichi
- Equipment Center, Kagawa Medical School
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- HOJO Satoko
- First Department of Internal Medicine, Kagawa Medical School
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- YAMAJI Yasufumi
- First Department of Internal Medicine, Kagawa Medical School
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- KAWANISHI Koichi
- Clinical Laboratory, Kagawa Medical School
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- TAKAHARA Jiro
- First Department of Internal Medicine, Kagawa Medical School
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Abstract
Macrolide antibiotics have a variety of actions other than antimicrobial activities. Recently, it has been suggested that macrolide antibiotics act as immunomodulators. In this study, we evaluated the effects of macrolide antibiotics on macrophage functions. For the macrophage, we used the mouse macrophage cell line J774.1. The following effects of macrolide antibiotics on macrophage functions were evaluated: the effect of macrolide antibiotics on macrophage growth; the phagocytosis of beads; cytocidal activity against Candida albicans; and chemotaxis to lipopolysaccharide (LPS). Macrolide antibiotics except for azithromycin significantly stimulated the growth of the macrophage. In addition, pretreatment with macrolide antibiotics except for roxithromycin significantly stimulated the macrophage phagocytosis of beads, macrophage chemotaxis to LPS, and macrophage cytocidal activity against Candida albicans. These results suggest that macrolide antibiotics stimulate macrophage functions.
Journal
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- MICROBIOLOGY and IMMUNOLOGY
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MICROBIOLOGY and IMMUNOLOGY 40 (7), 473-479, 1996-07-20
Center For Academic Publications Japan
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Details
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- CRID
- 1571417124231427584
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- NII Article ID
- 10004893233
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- NII Book ID
- AA00738350
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- ISSN
- 03855600
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- Text Lang
- en
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- Data Source
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- CiNii Articles