Pentoxifylline Pretreatment Enhances the Oxidative Burst Activity of Human Peripheral Blood Mononuclear Cells

• CHANG Feng-yee

  Division of Infectious Disease and Tropical Medicine, Department of Internal Medicine

• SHAIO Men-fang

  Department of Parasitology and Tropical Medicine, National Defense Medical Center

抄録

The effect of pentoxifylline pretreatment on the lucigenin-augmented chemiluminescence and dismutase-inhibitable superoxide production of human neutrophils and mononuclear cells (MNCs) was studied. Pentoxifylline at 20-2, 000μg/ml enhanced the lucigenin-augmented chemiluminescence (118-165% of the control, P<0.01) of phorbol myristate acetate (PMA)-stimulated MNC. Pentoxifylline at 20-2, 000μg/ml increased the MNC superoxide production, i.e., 142-171% of the control (P<0.05) using PMA stimulation and 145-159% of the control (P<0.01) using opsonized zymosan stimulation. In contrast, pentoxifylline (up to 2, 000μg/ml) did not influence the lucigenin-augmented chemiluminescence and superoxide production of human neutrophils, stimulated by either PMA or opsonized zymosan. These results suggest that pentoxifylline is an immunomodulator and may have potential usefulness in the enhancement of immune defenses in compromised hosts.

収録刊行物

• Microbiology and immunology

  Microbiology and immunology 40 (10), 787-790, 1996-10-20

  財団法人 学会誌刊行センター

キーワード

• Pentoxifylline
• Monocyte
• Oxidative burst
• Superoxide

詳細情報

• CRID: 1573950399022066176
• NII論文ID: 10004894583
• NII書誌ID: AA00738350
• ISSN: 03855600
• Web Site: http://chemport.cas.org/cgi-bin/sdcgi?APP=ftslink&action=reflink&origin=jstage2&version=1.0&coi=1:CAS:528:DyaK2sXhtFam&md5=9ac5b486ef58b70ca6f000f8ca0af7fe
• Web Site: https://search.jamas.or.jp/link/ui/1997042407
• 本文言語コード: en
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