Adjuvanticity of an Ornithine-Containing Lipid of Flavobacterium meningosepticum as a Candidate Vaccine Adjuvant

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Ornithine-containing lipids (OrnL) extracted from <i>Flavobacterium meningosepticum</i> have been reported to have various biological activities such as B-cell mitogenicity and macrophage activation to generate interleukin-1 and prostaglandin E<sub>2</sub>. We, using ovalbumin (OVA) as an antigen, evaluated the adjuvant activity of OrnL as an immunological adjuvant in BALB/c mice. OrnL showed the function of forming liposome-like vesicles retaining biological activities when prepared as either small unilamellar or dehydration-rehydration vesicles. Although OrnL was not shown to have enough entrapping efficacy for use as a vaccine adjuvant, phosphatidylglycerol (PG) and cholesterol (CHOL) added to stabilize the vesicle membrane increased the entrapping efficacy to the same extent as that of conventional liposomes. Furthermore, the stabilized OrnL vesicles tolerated centrifugation to remove non-entrapped antigens. Completely antigen-entrapped OrnL vesicles including PG and CHOL induced a significantly greater enhancement of IgG antibody production than did aluminum hydroxide gel in BALB/c mice from week 6. These results indicate that OrnL can be utilized as an immunological adjuvant for vaccines.

収録刊行物

  • Microbiology and immunology  

    Microbiology and immunology 41(2), 101-106, 1997-02-20 

    Center For Academic Publications Japan

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各種コード

  • NII論文ID(NAID)
    10004895638
  • NII書誌ID(NCID)
    AA00738350
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03855600
  • NDL 記事登録ID
    4153792
  • NDL 雑誌分類
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL 請求記号
    Z53-M387
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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