Ultrastructural Alterations of Candida albicans Induced by a New Imidazole Antimycotic Omoconazole Nitrate

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The antifungal effects of an imidazole-antimycotic omoconazole nitrate (OMZ) on the morphology and ultrastructure of <i>Candida albicans</i> yeast cells were studied using scanning and transmission electron microscopy. The treatment of growing <i>Candida</i> cultures with fungistatic doses (0.4 to 4μg/ml) of OMZ produced the formation of a chain or cluster of cells. Thickening of the cell wall and accumulation of electron-dense vesicles in the wall were clearly observed. Development of Golgi-like complex membranous structures in the cytoplasm was the most prominent finding. The cytological alteration induced by exposure to a higher concentration (40μg/ml) of the drug was characterized by disruption of the intracytoplasmic organelles. Our results confirm the strong antifungal activity of OMZ against fungal cells.

収録刊行物

  • Microbiology and immunology

    Microbiology and immunology 41(5), 395-402, 1997-05-20

    Center For Academic Publications Japan

参考文献:  32件中 1-32件 を表示

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各種コード

  • NII論文ID(NAID)
    10004896754
  • NII書誌ID(NCID)
    AA00738350
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03855600
  • NDL 記事登録ID
    4209560
  • NDL 雑誌分類
    ZS9(科学技術--医学--病理学・微生物学・寄生虫学・感染・免疫学・血清学・アレルギー)
  • NDL 請求記号
    Z53-M387
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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