Ultrastructural Alterations of Candida albicans Induced by a New Imidazole Antimycotic Omoconazole Nitrate
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The antifungal effects of an imidazole-antimycotic omoconazole nitrate (OMZ) on the morphology and ultrastructure of <i>Candida albicans</i> yeast cells were studied using scanning and transmission electron microscopy. The treatment of growing <i>Candida</i> cultures with fungistatic doses (0.4 to 4μg/ml) of OMZ produced the formation of a chain or cluster of cells. Thickening of the cell wall and accumulation of electron-dense vesicles in the wall were clearly observed. Development of Golgi-like complex membranous structures in the cytoplasm was the most prominent finding. The cytological alteration induced by exposure to a higher concentration (40μg/ml) of the drug was characterized by disruption of the intracytoplasmic organelles. Our results confirm the strong antifungal activity of OMZ against fungal cells.
- Japanese Journal of Microbiology
Japanese Journal of Microbiology 41(5), 395-402, 1997-05-20
Center For Academic Publications Japan