EVALUATION OF THE ACTIVITY AND EFFECTS OF COMBINATIONS OF VARIOUS ANTIBACTERIAL AGENTS AGAINST METHICILLIN-RESISTANT Staphylococcus aureus IN VITRO

• KOUDA MASAKAZU

  First division of Clinical Laboratories, Tokyo Metropolitan Police Hospital

• HOMMA SHOKO

  First division of Clinical Laboratories, Tokyo Metropolitan Police Hospital Internal Medicine, Tokyo Metropolitan Police Hospital

• UDAGAWA IKUKO

  First division of Clinical Laboratories, Tokyo Metropolitan Police Hospital

• FUKUHARA JUNKO

  First division of Clinical Laboratories, Tokyo Metropolitan Police Hospital

• TAKEUCHI MIKA

  First division of Clinical Laboratories, Tokyo Metropolitan Police Hospital

• TAMURA KEIKO

  First division of Clinical Laboratories, Tokyo Metropolitan Police Hospital

Bibliographic Information

Other Title

• MRSAに対する各種抗菌薬の抗菌力とin vitro併用効果

Abstract

MICs of various antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) were measured. Furthermore, we evaluated the effects of combinations of antibacterial agents against MRSA in vitro.<BR>In 24 cases out of 37, in which MRSA was isolated from inpatients, other microorganisms, such as Candida spp., Entrococcus spp., and Pseudomonas aeruginosa, were simultaneously isolated.<BR>From the results of minimum inhibitory concentrations (MICs), obtained from micro broth-dilution method, of various antibacterial agents against MRSA, range of MICs of arbekacin (ABK), vancomycin (VCM) and teicoplanin (TEIC) were<0.25-4.0, 0.5-1.0 and 0.25-4.0μg/ml respectively, and no strains of MRSA showed resistance to ABK, VCM and TEIC, so that we concluded that these three antibacterial agents were effective for MRSA infection.<BR>On the in vitro study of combination-effect of antibacterial agents, significant synergistic effects were achieved in the combination of VCM and flomoxef (FMOX)(Synergism rate was 97.3%) or VCM and imipenem (IPM)(Synergism rate was 97.2%). From the results that the fractional inhibitory concentration index in the combination of VCM with IPM was smaller than that with FMOX and that P. aeruginosa orEnterococcus spp. were simultaneously isolated in high frequency in the MRSA-isolated cases, we thought that the combination of VCM with IPM is more useful, because IPM is effective against P. aeruginosa but FMOX is not.

Journal

• The Japanese Journal of Antibiotics

  The Japanese Journal of Antibiotics 53 (3), 171-178, 2000

  Japan Antibiotics Research Association

Details

• CRID: 1390001205496533120
• NII Article ID: 130004395883
• NII Article ID: 10004899357
• NII Book ID: AN00002626
• DOI: 10.11553/antibiotics1968b.53.171
• COI: 1:CAS:528:DC%2BD3cXitlSit7g%3D
• ISSN: 21865477
• ISSN: 03682781
• PubMed: 10834148
• Web Site: https://search.jamas.or.jp/link/ui/2000194303
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed