PHARMACOKINETIC, BACTERIOLOGICAL AND CLINICAL STUDIES ON AZITHROMYCIN IN CHILDREN
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- TAJIMA TAKESHI
- Department of Pediatrics, Teikyo University School of Medicine
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- KOBAYASHI MASAAKI
- Department of Pediatrics, Teikyo University School of Medicine
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- ABE TOSHIAKI
- Department of Pediatrics, Teikyo University School of Medicine
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- FUJII RYOCHI
- Emeritus Professor, Department of Pediatrics, Teikyo University School of Medicine Research Institute of Chemothrapy for Mother and Child
Bibliographic Information
- Other Title
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- 小児における Azithromycin の基礎的・臨床的検討
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Abstract
Azithromycin (AZM) in fine granules was studied for its phamacokinetics and clinical efficacies in eight child patients with ages between 1 month and 8 years. Informed consent was received from all of their parents. AZM was administered to the patients once a day at a dose of 10 mg/kg for 3 days.<BR>The clinical efficacies of AZM in 8 patients with microbial infections (pneumonia in one, Mycoplasma pneumonia in two, acute tonsillitis in one, pertussis in one, Campylobacter enteritis in one, infectious enteritis in one, Salmonella enteritis in one) were evaluated as “excellent” in five cases, “good” in two and “not evaluable” in one. As for the microbial efficacy, isolated strains were eradicated in 2 out of 3 patients.<BR>No adverse reaction was found except for one case with abnormal laboratory change, that is mildly increased GPT value.<BR>Plasma samples were collected from 3 cases. The elimination half-life of AZM was 45.8 hours. AUC-∞was 12.6 μg hr/ml. Urine sample was collected from one. AZM concentration in urine was 35.0μg/ml during a period between 48 and 72 hours after the start of treatment.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 50 (2), 200-205, 1997
Japan Antibiotics Research Association
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Details 詳細情報について
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- CRID
- 1390282680473620352
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- NII Article ID
- 130004395795
- 10004899870
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- NII Book ID
- AN00002626
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- COI
- 1:CAS:528:DyaK2sXhslWqtb8%3D
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- ISSN
- 21865477
- 03682781
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- PubMed
- 9100080
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed