PHARMACOKINETIC AND CLINICAL EVALUATION OF AZITHROMYCIN IN THE PEDIATRIC FIELD
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- KITAMURA KENJI
- Department of Pediatrics, Mie National Hospital
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- KAMIYA HITOSHI
- Department of Pediatrics, Mie National Hospital
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- NAKANO TAKASHI
- Department of Pediatrics, School of Medicine, Mie University
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- SAKURAI MINORU
- Department of Pediatrics, School of Medicine, Mie University
Bibliographic Information
- Other Title
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- 小児科領域におけるAzithromycinの薬物動態と臨床的検討
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Abstract
35 children between 9 months and 12 years of ages were gi ven 9.1 to 12.2 mg/kg of azithromycin (AZM) once a day for 3 days. In the treatment of pediatric infectious diseases, we studied pharmacokinetics, efficacy and safetiness of AZM. After administration of 10 mg/kg/day of AZM for 3 days, the elimination half-life was calculated to be 38.2±1 16.3 hours (n= 6, mean±S. D.). The excretion rate of AZM in the urine within 120 hours of administration was 9.0±2.3% (n= 5). For the evaluation of efficacy of AZM, we treated 33 cases of children with pharyngotonsillitis, bronchitis, mycoplasma bronchitis, pneumonia, mycoplasma pneumonia, atypical pneumonia, and SSTI. The efficacy rate of these cases were 93.9%. 6 strains of bacteria were identified as causative agents. All strains were eradicated upon the treatment. One case of elevated GOT and GPT and two cases of elevated GPT were observed. No clinical adverse reactions were observed.<BR>In conclusion, AZM was useful for the treatment of pediatric infectious diseases we examined.
Journal
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- The Japanese Journal of Antibiotics
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The Japanese Journal of Antibiotics 50 (2), 206-214, 1997
Japan Antibiotics Research Association
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Details 詳細情報について
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- CRID
- 1390282680473622656
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- NII Article ID
- 130004395796
- 10004899880
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- NII Book ID
- AN00002626
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- COI
- 1:CAS:528:DyaK2sXhslWqtbw%3D
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- ISSN
- 21865477
- 03682781
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- PubMed
- 9100081
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed