マウス日和見感染モデルにおける乳酸菌Ｅｎｔｅｒｏｃｏｃｃｕｓ　ｃａｓｓｅｌｉｆｌａｖｕｓ菌体の感染予防効果

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  • Prophylactic Effect of Enterococcus casseliflavus NF-1004 Preparation on the Lethal Infection of Mice with Opportunistic Pathogens.

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The prophylactic effect of an Enterococcus casseliflavus NF-1004 preparation on the lethal infection of mice with opportunistic pathogens was investigated. In cyclophosphamide-induced leukopenic mice, both intraperitoneal (i. p.) and oral administration of NF-1004 preparation prior to Candida albicans infection significantly prolonged survival periods of the infected mice, and decreased viable counts of C. albicans in their kidneys. NF-1004 preparation was also prophylactic in normal mice, although less effective, against C. albicans infection. In leukopenic mice i. p. administration of NF-1004 preparation was protective against lethal infection by Pseudomonas aeruginosa or Staphylococcus aureus. These results point to the potential usefulness of NF-1004 preparation as a prophylactic agent for opportunistic infections.

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