肺転移巣を切除した胃癌5症例の検討  糖鎖抗原の発現と転移について

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  • Five cases of surgically resected pulmonary metastases from gastric cancer: relation between the expression of carbohydrate antigens and metastasis.

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We report five rare cases of gastric cancer with resected pulmonary metastatic lesions. Their primary and metastatic lesions were compared for clinical pathological findings, and for immunohistochemical findings of expression of the carbohydrate antigens, SLX and CA19-9. Based on the mode of metastasis, three of the five cases were considered to be able to have further resection of recurrent pulmonary metastatic lesions. These three cases appeared to have a tendency to form metastatic nests preferentially in the lung, and shared common features such as pathologically differentiated (intestinal type) metastatic lesions and the positive expression of CA19-9. Of these three cases, one has survived for more than 5 years with weaker SLX expression in the metastatic site than in the primary. The present cases suggest the possibility that the carbohydrate antigens of gastric cancer may play a role in the formation of pulmonary nodular lesions due to metastasis of gastric cancer and in patient's prognosis.

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