Rapid Determination of Benzene Metabolites Phenol and p-Cresol in the Urine of Petrol Station Workers by Gas Chromatography

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抄録

The determination of phenol and p-cresol in urine has been suggested as a suitable biomarker for the monitoring of benzene exposure of pump workers employed in petrol stations. A method for efficiently extracting a wide variety of drugs from urine for toxicological analysis by gas chromatography is presented. The sensitivity of the method is sufficient to monitor normal levels of phenol and p-cresol after exposure to benzene vapors. The detection limit of the method is low enough to measure urinary phenol and p-cresol at a concentration of 0.1 mg/l. The overall recoveries of urinary phenol and p-cresol relative to the internal standard, DPA, ranged between 95 and 96.5%. Our gas chromatographic method is a rapid, precise and economical one suitable to measure the metabolite benzene also in routine monitoring of phenol and p-cresol.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry  

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 16(6), 589-591, 2000-06-10 

    社団法人 日本分析化学会

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各種コード

  • NII論文ID(NAID)
    10004955025
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • NDL 記事登録ID
    5380251
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z54-F482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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