Kinetic Spectrophotometric Determination of Sulbutiamine in Pharmaceutical Preparations and in Human Serum

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A kinetic spectrophotometric method was developed for the determination of sulbutiamine based on the catalytic effect on the reaction between sodium azide and iodine in an aqueous solution. Sulbutiamine at concentrations of 0.5 to 20 µg/ml was determined by measuring the decrease in the absorbance of iodine at 348 nm by a fixed-time method. The decrease in the absorbance in the first 5 min from the initiation of the reaction is related to the concentration of the drug. The detection limit of the procedure was 0.2 µg/ml. The relative standard deviation for the replicate determination (n = 10) of 4 µg/ml was 1.05%. The proposed procedure was successfully utilized in the determination of the drug in pharmaceutical preparations and human serum.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry  

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 16(6), 633-636, 2000-06-10 

    社団法人 日本分析化学会

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各種コード

  • NII論文ID(NAID)
    10004955204
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • NDL 記事登録ID
    5380282
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z54-F482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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