肝細胞癌に対する経皮的マイクロ波凝固療法　肝切除例における治療効果判定を中心として

DOI PubMed 被引用文献2件 参考文献14件

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  • Percutaneous microwave coagulation therapy for hepatocellular carcinoma. Study on its therapeutic effect in surgical cases.
  • ―肝切除例における治療効果判定を中心として―

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Six patients with hepatocellular carcinoma were subjected to percutaneous microwave coagulation therapy (PMCT) by ultrasonic guiding. The size of the main tumor in the present cases was limited to not more than 2 cm. From 18 to 48 days after PMCT, each patient was subjected to surgery and pathological examination.<BR> By macroscopic observation, the PMCT area including both non-tumor and tumor regions looked yellowish white, and the boundary was clearly recognized. In the histological examination, the coagulation area surrounded by fibrous capsule was found, and deletion of nuclei and changes in stainability were observed in the marginal region. These changes indicated obvious coagulation necrosis, but the changes became less intense toward the center in the area, and in some portions, the tissue was indistinguishable from viable cells by light microscopy. In 2 cases out of the 6, part of the tumor remained outside the coagulation area. Since only the area determined by the microwave electorode is coagulated to cause necrosis on PMCT, sufficient safety margin should be required.

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