90%肝大量切除後の残肝障害発生へのbacterial translocation関与に関する実験的検討 polymyxin B経口投与による腸内グラム陰性かん菌除去効果
書誌事項
- タイトル別名
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- Bacterial translocation induces remnant liver injury after subtotal (90%) hepatectomy in rats. The effect of decontamination of gram-negative rods in digestive tract by oral polymyxin B treatment.
- ―polymyxin B経口投与による腸内グラム陰性桿菌除去効果―
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抄録
To clarify the relationship of bacterial translocation (BT) to remnant liver injury after subtotal (90%) hepatectomy, we compared orally polymyxin B treated rats (PL-B (+)), of which gram-negative rods (GNR) in digestive tract decreased, with control rats (PL-B (-)). The increase in intestinal permeability assessed by lactulose/mannitol ratio in urine, the increase in GNR positive in tissue culture including mesenteric lymphnode, liver, spleen, portal blood, and kidney, and the elevation of serum endotoxin levels showed BT after subtotal hepatectomy in PL-B (-) group. Liver injury was also observed by increased serum GPT levels and massive coagulative necrosis of hepatocytes with bleeding in the remnant liver. In PL-B (+) group rats, BT and liver injury decreased and hepatocyte DNA synthesis increased, while intestinal permeability was the same as PL-B (-) group. It is suggested that BT is the cause of remnant liver injury after subtotal hepatectomy, and oral PL-B treatment is effective in preventing liver injury.
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 93 (8), 544-552, 1996
一般財団法人 日本消化器病学会
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詳細情報 詳細情報について
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- CRID
- 1390282681374934656
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- NII論文ID
- 10005017530
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- NII書誌ID
- AN00192124
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- COI
- 1:CAS:528:DyaK28XlslCksbw%3D
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- ISSN
- 13497693
- 04466586
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- PubMed
- 8810811
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可