A Case of Duodenal Low-Grade Mucosa-Associated Lymphoid Tissue Lymphoma which did not Respond to Eradication Therapy for Helicobacter Pylori Infection.

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  • Ｈｅｌｉｃｏｂａｃｔｅｒ　ｐｙｌｏｒｉの除菌治療が無効であった十二指腸ｌｏｗ‐ｇｒａｄｅ　ＭＡＬＴリンパ腫の１例

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Abstract

This case report described a 54-year old woman with multiple small erosions and elevated lesions in the proximal descending duodenum diagnosed histopathologically as low-grade mucosa-associated lymphoid tissue lymphoma (MALToma). She was infected with helicobacter pylori, and we atternpted to eradicate. H. pylori with quadruple therapyconsisting of omeprazole, bismuth subnitrate, amoxicillin and metronidazole. Cure of theinfection was proved one and three months after the end of therapy by culture, histology and urea breath test. The lesions, however, remained unchanged during five months follow-up after the therapy. Thus the surgical procedure of partial duodenectomy was performed. The histologic study of the resected specimen revealed that infiltration of centracyte-like cells was limited to the submucosa. Although there are a few reports on regression of duodenal MALToma after eradication of H. pylori, anti-H. pylori therapy was not effective for our patient.

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