腹腔鏡・肝生検にて確定診断し得た肝原発Ｅｐｉｔｈｅｌｉｏｉｄ　Ｈｅｍａｎｇｉｏｅｎｄｏｔｈｅｌｉｏｍａの１例

DOI 被引用文献5件 参考文献13件

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  • A Case of Epithelioid Hemangioendothelioma of the Liver Diagnosed by Laparoscopy and Histological Findings, Followed up during ten years.

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A 24-year-old female, who had been followed up due to liver cirrhosis and atypical hepatocellular carcinoma at a hospital, was admitted to our hospital, complaining of hepatosplenomegaly and right upper abdominal pain. Ultrasonography, CT and MRI images revealed multiple SOLs without enhancement throughout both lobes of the liver, but deffinite diagnosis could not be done. With laparoscopic examination, these tumors were yellow-white and firm to hard. The main tumors of 3 to 4 cm in diameter were located along the anterior surface of the liver. Fine vessels were developping around the main tumor. The histological findings taken from the tumor disclosed spindle-shaped tumor cells scattering in f ibromyxoid stroma. These tumor cells were invading into hepatic sinusoids and showed positive staining for factor VIII-related antigen immunohistochemically, suggesting that this case is compatible with epithelioid hemangioendothelioma (EHE) of the liver. She underwent systemic IL-2 administration but it was not effective on the tumor. Although she is alive ten years later from diagnosis, tumors are expanding throughout the liver, presenting diffuse type of EHE.

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