市販下剤によるメラノーシスコリ発症動物モデルの作成

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  • Preparation of Animal Model of Melanosis Coli Induced by Continuous Administration of Clinically Avilable Laxative.

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Melanosis coli develops by longterm taking of stimulative laxatives such as senna and aloe, and the organic changes are thought not only to be limited to the mucosa but to spread to the nerveplexus of the intestinal wall which exacerbates constipation. However the pathogenesis or pathophysiologily is not fully yet clarified. Therefore, formation of the experimental animal model is considered to be needed and for the purpose, male guinea pigs are administrated with commercially available sennocot® granules containing anthraquinon. The dose was speculated the adult dose. When the exssesive doses were administrated to guinea pigs, grossly the colon showed black staining, and the histologically deposition of brownish pigmented granules in the submucosa were observed. The pathological chenges of the model were similar to those of the human. The amount of pigment diposition basically depended on or well corelate with the administrated amount, which shows administration of the drug makes melanosis coli. The pigmental deposit occured in the cecum and almost not in the colon and rectum. The melanosis coli thus formed experimentally will be useful to the clarification of the pathogenesis.

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