選択的ホスホジエステラーゼＩＩＩ阻害剤アムリノンによるラット頚動脈新生内膜肥厚抑制作用

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  • Effects of amrinone, an inhibitor of c-AMP-specific phosphodiesterases, on neointimal hyperplasia after balloon injury in rats.
  • センタクテキ ホスホジエステラーゼ 3 ソガイザイ アムリノン ニヨル ラット

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Amrinone (5-amino (3, 4'-bibyridin) 6- (1H) -one), an inhibitor of c-AMP-specific phosphodiesterases, has been used clinically as an inodilator. We have investigated the effect of amrinone on neointimal hyperplasia inrat carotid artery after balloon injury. When amrinone was administered subcutaneously to rats at a dose of 10 mg/kg/day for 14 days, significant reduction of neointimal thickness was noted. Four days treatment with amrinone, however, failed to reduce the intimal thickness. To investigate the mode of action to reduce intimal thickness, we tried to study the effects of amrinone on platelet aggregation and the proliferation of aortic smooth muscle cells. Amrinone produced a dose-dependent inhibition of ADP-induced rat platelet ag-gregation in vitro as well as ex vivo in rats. The proliferation of human aortic smooth muscle cells in culture stimulated with FBS or PDGF was also inhibited by amrinone. These results indicate that amrinone may have potential to prevent vascular neointimal hyperplasia in clinical balloon injury through inhibition of vascular smooth muscle cell growth and platelet aggregation.

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  • 日本薬理学雑誌

    日本薬理学雑誌 112 (4), 267-274, 1998

    公益社団法人 日本薬理学会

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