CD8+-T-cell-rich B-cell lymphoma presenting in skin and bone.

  • Hyodo Takayuki
    The First Department of Internal Medicine, Ehime University School of Medicine
  • Yakushijin Yoshihiro
    The First Department of Internal Medicine, Ehime University School of Medicine
  • Iwamasa Kikue
    The First Department of Internal Medicine, Ehime University School of Medicine
  • Sakai Ikuya
    The First Department of Internal Medicine, Ehime University School of Medicine
  • Hasegawa Hitoshi
    The First Department of Internal Medicine, Ehime University School of Medicine
  • Yasukawa Masaki
    The First Department of Internal Medicine, Ehime University School of Medicine
  • Fujita Shigeru
    The First Department of Internal Medicine, Ehime University School of Medicine

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  • 皮膚および骨に発症したCD8`+´‐T‐cell‐rich B‐cell lymphoma

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Abstract

症例は82歳,男性. 1997年11月右肩関節に皮膚腫瘤,左膝関節に骨破壊が出現.生検にて両病変部にリンパ球の腫瘍性の浸潤を認めた.免疫組織染色およびフローサイトメトリーによる解析では,皮膚・骨ともに小型のCD8陽性T細胞が約9割を占めB細胞は1割に満たなかった.一方,腫瘤組織を用いたサザンブロット解析ではTcR遺伝子の再構成は認めず, IgH遺伝子の再構成を認めたことから本症例をCD8+-T-cell-rich B-cell lymphomaと診断した.

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