カルシウムきっ抗薬ＳＭ‐６５８６のＳＨＲを用いた実験的脳虚血に及ぼす効果の検討　生存率，脳浮腫および脳代謝

• 柏木 史彦

  日本医科大学第二内科 M.D.

• 五十嵐 博中

  日本医科大学第二内科 M.D.

• 片山 泰朗

  日本医科大学第二内科 M.D.

• 赫 彰郎

  日本医科大学第二内科 M.D.

書誌事項

タイトル別名

• Effects of calcium antagonist (SM-6586) on cerebral edema and metabolism in forebrain and focal ischemia.
• -生存率, 脳浮腫および脳代謝-

抄録

SM-6586 (SM) is a new derivative of dihydronyridine with a potent calcium blocking activity and an inhibitory activity of Na⁺/H⁺ and Na⁺/Ca⁺⁺ exchange transport. The effects of SM on survival rate, brain edema and metabolites were evaluated using a global ischemic model in spontaneously hypertensive rats (SHR). Further, the effects of SM on the brain water content and T1 relaxation time using NMR were examined in focal cerebral ischemia. Global ischemia was induced by bilateral common carotid artery ligation (BLCL), and focal ischemia was induced by middle cerebral artery occlusion. The survival rate after BLCL was higher in the SM-treated group. The brain water content was lower, the ATP levels were higher and the lactate levels were lower in the SM-treated group as compared to the control group. In the focal ischemia model, the SM-treated group showed a reduction in T1 relaxation time. Also, the brain water content was significantly decreased in the SM-treated group. These results indicate that SM was effective in ameliorating the ischemic insult in both the global and focal cerebral ischemia models.

収録刊行物

• 脳卒中

  脳卒中 15 (5), 333-339, 1993

  一般社団法人 日本脳卒中学会

キーワード

• Ca<SUP>++</SUP>antagonist
• cerebral ischemia
• brain edema
• metabolism
• SHR

詳細情報

• CRID: 1390001204639814656
• NII論文ID: 130003631298
• NII論文ID: 10005236885
• NII書誌ID: AN0020186X
• DOI: 10.3995/jstroke.15.333
• DOI: 10.3995/jstroke.19.333
• ISSN: 18831923
• ISSN: 09120726
• Web Site: https://search.jamas.or.jp/link/ui/1998191084
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可