書誌事項
- タイトル別名
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- Influence on glycemic control of improved diabetic gastroparesis by long-term cisapride therapy.
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抄録
To investigate the effect on glycemic control of improving diabetic gastroparesis, we evaluated symptoms (scored), gastric motor functions (solid and liquid gastric emptying studies and electrogastrography), and glycemic control in 11 patients with diabetic gastroparesis (5 men, 6 women, 50.4±4.5 years old) before and after treatment with cisapride (15 mg/day p.o., 12 weeks). None of the patients had organic abnormalities on gastrointestinal endoscopy. The dysmotility symptom score (maximum :18) on cisapride significantly improved from 13.1 to 4.0 (p<0.01). Retention rates at 15 and 80 minutes after ingestion improved in a solid-food gastric emptying study using a test meal of instant noodles labeled with 37 MBq (1 mCi) technetium-99m (both p<0.05). Liquid gastric emptying, evaluated using a sulfamethizole technique, also improved but not significantly. Electrogastrography revealed no significant changes after treatment, but the postprandial rate of normal frequency waves tended to increase. Glycemic control was assessed based on HbA1C, fructosamine and M value. There were no significant changes in glycemic control after treatment with cisapride.<BR> We conclude that long-term administration of cisapride reduced dysmotility symptoms and improved solid and liquid gastric emptyings without adversely affecting glycemic control.
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 92 (10), 1724-1733, 1995
一般財団法人 日本消化器病学会
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詳細情報 詳細情報について
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- CRID
- 1390001206395389952
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- NII論文ID
- 10005242981
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- NII書誌ID
- AN00192124
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- COI
- 1:STN:280:BymD2Mnptlc%3D
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- ISSN
- 13497693
- 04466586
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- PubMed
- 7474464
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可