書誌事項
- タイトル別名
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- A study of colonic mucins in two kinds of experimental colitis model in rat.
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We investigated the quantitative changes in colonic mucins of rats with colitis. Male Wistar rats were treated with dextran sodium sulfate (DSS) or N-ethylmaleimide (NEM) to induce colitis. Both DSS and NEM caused depletion of goblet cells, infiltration of inflammatory cells and erosion at the colonic mucosa around the anus. Though the goblet cells decreased, colonic mucins increased in the distal colon. These phenomena may explain the clinical features of human ulcerative colitis, namely the goblet cell depletion and the mucous stool. The increase of colonic mucins may be a compensatory function of the colon tissue in response to the localized decrease of mucin production.
収録刊行物
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- 日本消化器病学会雑誌
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日本消化器病学会雑誌 95 (6), 513-523, 1998
一般財団法人 日本消化器病学会
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キーワード
詳細情報
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- CRID
- 1390282681373580288
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- NII論文ID
- 10005243420
- 10011142457
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- NII書誌ID
- AN00192124
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- COI
- 1:CAS:528:DyaK1cXltVaiu7w%3D
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- ISSN
- 13497693
- 04466586
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- PubMed
- 9656713
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可