書誌事項
- タイトル別名
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- Significance of serum HCV RNA titer, determined by branched DNA probe assay, in patients with chronic hepatitis C treated with interferon (IFN).
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Serum HCV RNA titer was determined by branched DNA probe assay (Quantiplex HCV, Chiron Diagnosis) in serial samples from 97 patients with chronic hepatitis C who received recombinant IFN-α 2b therapy. In 30 (31%) of the patients, the pretreatment titer was below the cut-off value (0.5Meq/ml). Complete response (CR) to IFN therapy was seen in 70%, 29% and 6% of patients in whom pretreatment titers were lower than 1.0Meq/ml, 1.0-10Meq/ml and more than 10Meq/ml, respectively. After 2 weeks of daily IFN administration, HCV RNA titers were below the cut-off value in all patients with CR, 88% of transient responders and 43% of non responders. The CR rate was significantly higher in HCV subtype III/2a and IV/2b than in subtype II/1b, given a similar titer of HCV RNA. When the patients were divided into 2 groups according to total dose of IFN (mean: 440MU), there was no significant difference in CR rate between the higher-dose group (more than 440MU) and the low-dose group in patients with III/ 2a or IV/2b. However, high-dose IFN was required in patients with subtype II/1b in order to obtain a CR rate similar to that for subtype III/2a and IV/2b, even in those with HCV RNA titer below 1.0Meq/ml.
収録刊行物
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- 肝臓
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肝臓 36 (10), 561-567, 1995
一般社団法人 日本肝臓学会
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詳細情報 詳細情報について
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- CRID
- 1390001204789924480
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- NII論文ID
- 10005253509
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- NII書誌ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可