Ｃ型慢性活動性肝炎におけるインターフェロン網膜症の発現頻度および発現要因に関する検討

• 関 孝一

  兵庫県立西宮病院内科

• 伊藤 芳晴

  市立川西病院内科

• 今井 康陽

  市立池田病院内科

• 垣本 洋希

  市立川西病院内科

• 原 拓

  市立川西病院眼科

• 西 泰雄

  市立川西病院眼科

• 猪阪 優子

  市立川西病院眼科

• 松本 直樹

  市立川西病院眼科

書誌事項

タイトル別名

• Incidence and risk factors for the development of interferon retinopathy in patients with type C chronic active hepatitis.

抄録

Incidence and risk factors for the development of interferon retinopathy were studied in patients with type C chronic active hapatitis. Eighty-eight patients without retinal change before interferon treatment were enrolled. Incidence of retinopathy was 25%; all the retinopathy developed within 12 weeks after the start of interferon treatment, the fastest onset being 2 weeks. Four variables including percent decrease in platelets and percent increase in triglyceride at 12 weeks after the beginning of interferon treatment, and HbA1C and mean blood pressure before the treatment have been selected by stepwise regression analysis for the development of interferon retinopathy. These results suggest that interferon retinopathy tends to develop in patients with diabetes mellitus or hypertension, and the decreas in platelets and the increase in triglyceride are other factors associated with interferon retinopathy. However, careful ophthalmologic follow-up enables interferon treatment to be continued.

収録刊行物

• 肝臓

  肝臓 36 (12), 690-696, 1995

  一般社団法人　日本肝臓学会

キーワード

• interferon網膜症
• C型慢性活動性肝炎
• interferon治療
• 重回帰分析

詳細情報

• CRID: 1390282679767075200
• NII論文ID: 10005253871
• NII書誌ID: AN00047770
• DOI: 10.2957/kanzo.36.690
• ISSN: 18813593
• ISSN: 04514203
• Web Site: http://www.jstage.jst.go.jp/article/kanzo1960/36/12/36_12_690/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996126478
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可