書誌事項
- タイトル別名
-
- Clinical efficacy of grepafloxacin in respiratory infections and its pharmacokinetics in sputum
この論文をさがす
抄録
We evaluated the clinical efficacy and safety of grepafloxacin (GPFX) in a phase 2 study in a total of seven patients with respiratory infections. GPFX was administered orally at a dose of 150 to 300mg daily. The time course of the serum and sputum concentrations was evaluated after administering a 300mg dose to one patient, and pharmacokinetic analysis was also performed. The subjects included one case each of bronchial asthma and diffuse panbronchiolitis, and five cases of bronchiectasis. Clinical response was good in three cases, fair in one and poor in two. Two strains of Haemophilus influenzae were eradicated, while three strains of Pseudomonas aeruginosa persisted in spite of their susceptibility to GPFX. One patient had headache and lumbago as well as chest discomfort four hours after taking GPFX. No abnormal laboratory findings were observed.<BR>The peak concentration of GPFX in sputum (four hours after administration) was 2.31μg/ml, almost two-fold that in serum, suggesting its efficacy in respiratory infections.
収録刊行物
-
- 日本化学療法学会雑誌
-
日本化学療法学会雑誌 43 (Supplement1), 239-243, 1995
公益社団法人 日本化学療法学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681260835712
-
- NII論文ID
- 10005466094
- 130004297178
-
- NII書誌ID
- AN10472127
-
- ISSN
- 18845886
- 13407007
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可