Ritipenem acoxilの呼吸器感染症に対する臨床的有用性の検討

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  • Basic and clinical studies on ritipenem acoxil

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We performed bacteriological and clinical studies on ritipenem acoxil (RIPM-AC), a new oral penem antibiotic, with the following results.<BR>1. The MIC90 of ritipenem (RIPM) against Staphylococcus aureus was 0.25 μg/ml, second to that of imipenem/cilastatin Na (IPM/CS) and superior to those of cefotiam (CTM), cefixime CFIX), cefpodoxime (CPDX) and ampicillin (ABPC). The MIC90, against Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenzae and Moraxella catarrhalis were 2 μg/ml, 1 μg/ml, 0.5 μg/ml and 1 μg/ml, respectively. RIPM was, however, weak against methicillin-resist ant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa.<BR>2. Twelve patients with respiratory infections were treated with RIPM-AC. The overall efficacy rate was 81.8%(excellent 1, good 8, fair 1, poor 1, unkown 1). No clinical side effects were observed, but elevation of S-GOT was observed in 2 cases after treatment.

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