書誌事項
- タイトル別名
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- <I>In vitro</I> activity, penetration to cerebrospinal fluid and clinical evaluation of balofloxacin in urinary tract infections
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We studied the in vitro activity, penetration to cerebrospinal fluid and clinical usefulness of balofloxacin (BLFX), a new oral fluoroquinolone.<BR>The in vitro activity of BLFX against 30 strains each of 11 species isolated from patients with urinary tract infections (UTI) was measured by the agar dilution method with an inoculum size of 106 CFU/ml. The drug showed activity superior to those of ofloxacin and tosufloxacin against gram-positive cocci and comparable with those against gram-negative bacteria.<BR>The mean ratio of cerebrospinal fluid level to serum level 2 hours after a single 200 mg oral dose in 4 patients who underwent transurethral surgery was 0.05.<BR>Six patients with acute uncomplicated cystitis (AUC) and 10 with chronic complicated UTI were treated with a daily dose of 100 mg to 400 mg of the drug for 3 to 5 days. The clinical efficacy rates of the drug against 6 cases of AUC and 7 cases of chronic complicated UTI as judged by the criteria proposed by the Japanese UTI Committee were 100% and 43%, respectively. No adverse reactions were observed in any of the 16 patients. Slight elevation of alkaline phosphatase was observed in one case.<BR>We conclude that BLFX is a useful drug in the treatment of UTI, especially that caused by grampositive cocci.
収録刊行物
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- 日本化学療法学会雑誌
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日本化学療法学会雑誌 43 (Supplement5), 330-335, 1995
公益社団法人 日本化学療法学会
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詳細情報 詳細情報について
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- CRID
- 1390001206288523648
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- NII論文ID
- 10005468791
- 130004297459
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- NII書誌ID
- AN10472127
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- ISSN
- 18845886
- 13407007
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可