ＮａｌＢ型排出蛋白質をもつ緑膿菌に対するＦＯＭとβ‐ラクタム薬の併用効果

DOI 被引用文献6件 参考文献14件

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  • Synergistic effects of fosfomycin (FOM) in combination with .BETA.-lactam antibiotics on NalB type Pseudomonas aeruginosa with efflux proteins.

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We obtained Pseudomonas aeruginosa strain R 1 from P. aeruginosa PAO 1 grown on an agar plate containing ofloxacin (OFLX) and cefsulodin (CFS). The sensitivity P. aeruginosa R 1 was altered to become more resistant to chloramphenicol (CP), tetracycline (TC), quinolones and β-lactam antibiotics than P. aeruginosa PAO 1, the parent strain. We studied bactericidal activities when TC, CP, ceftadidime (CAZ), sulbactam/cefoperazone (SBT/CPZ) were combined with fosfomycin (FOM). The combination of FOM with CAZ, SBT/CPZ or β-lactam antibiotics, had a synergistic effect, but TC and CP which are also pumped-out by efflux proteins were not affected. More CPZ accumulated in the periplasm of P. aeruginosa R 1 treated with FOM than in the untreated bacteria. It was concluded that FOM synergistically potentiated the bactericidal activity of β-lactam antibiotics against Na1B type P. aeruginosa with the efflux proteins.

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