TMC-1 A, B, C and D, New Antibiotics of the Manumycin Group Produced by Streptomyces sp. Taxonomy, Production, Isolation, Physico-chemical Properties, Structure Elucidation and Biological Properties.

DOI Web Site PubMed 被引用文献7件 参考文献16件
  • KOHNO JUN
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • NISHIO MAKI
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • KAWANO KIMIO
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • NAKANISHI NORIYUKI
    Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.
  • SUZUKI SHIN-ICHI
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • UCHIDA TOMOFUMI
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.
  • KOMATSUBARA SABURO
    Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd.

書誌事項

タイトル別名
  • TMC-1 A B C and D New Antibiotics of th
  • Taxonomy, Production, Isolation, Physico-chemical Properties, Structure Elucidation and Biological Properties

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抄録

Four new antitumor antibiotics, TMC-1 A, B, C and D were isolated from a fermentation broth of Streptomyces sp. A-230. Spectroscopic studies have shown that TMC-1 A to D were new members of the manumycin class of antibiotics. These antibiotics showed cytotoxic activities against various tumor cell lines in vitro.

収録刊行物

  • The Journal of Antibiotics

    The Journal of Antibiotics 49 (12), 1212-1220, 1996

    公益財団法人 日本感染症医薬品協会

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