Antifungal Antibiotic Benanomicin A Increases Susceptibility of Candida albicans to Phagocytosis by Murine Macrophages.

  • WATABE HIROOMI
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
  • MIKUNIYA TAKESHI
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.
  • INOUYE SHIGEHARU
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd. Present address: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University
  • ABE SHIGERU
    Department of Microbiology and Immunology, Teikyo University School of Medicine
  • YAMAGUCHI HIDEYO
    Department of Microbiology and Immunology, Teikyo University School of Medicine
  • KONDO SHINICHI
    Institute of Microbial Chemistry
  • TAKEUCHI TOMIO
    Institute of Microbial Chemistry
  • KLEIN THOMAS W.
    Department of Medical microbiology and immunology, University of South Florida College of Medicine
  • FRIEDMAN HERMAN
    Department of Medical microbiology and immunology, University of South Florida College of Medicine
  • YAMAMOTO YOSHIMASA
    Department of Medical microbiology and immunology, University of South Florida College of Medicine

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タイトル別名
  • Antifungal Antibiotic Benanomicin A Inc

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抄録

Benanomicin A is an antifungal antibiotic produced by Actinomadura spadix. In the present study, we investigated the effect of benanomicin A on the phagocytosis of Candida albicans by murine peritoneal macrophages and on the cell-surface hydrophobicity (CSH) of C. albicans. Although pretreatment of macrophages with benanomicin A had no effect on the phagocytosis, addition of benanomicin A to the culture of macrophages and Candida cells increased the susceptibility of Candida cells to the phagocytosis by the macrophages. Pretreatment of Candida cells with benanomicin A also increased the susceptibility of Candida cells to the phagocytosis. When Candida cells were mixed with benanomicin A, the antibiotic bound irreversibly to Candida cells. These data suggest the possibility that the increased susceptibility of Candida cells to the phagocytosis is mediated by the binding of benanomicin A to Candida cells. Examination of physicochemical property of Candida cell surface showed that the CSH of Candida cells significantly decreased by the treatment with benanomicin A. Thus, binding of benanomicin A to Candida cells may induce biochemical/physicochemical alternation of the surfaces, so that they become more susceptible to phagocytosis by murine macrophages. These properties of benanomicin A, along with its antifungal activity, seem to be beneficial in the treatment of fungal infections.

収録刊行物

  • The Journal of Antibiotics

    The Journal of Antibiotics 49 (12), 1221-1225, 1996

    公益財団法人 日本感染症医薬品協会

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