Branched-Chain Amino Acid Therapy for Spinocerebellar Degeneration: A Pilot Clinical Crossover Trial.
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- MORI Nozomi
- Division of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine
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- ADACHI Yoshiki
- Division of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine
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- TAKESHIMA Takao
- Division of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine
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- KASHIWAYA Yoshihiro
- Division of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine
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- OKADA Akitsugu
- Division of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine
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- NAKASHIMA Kenji
- Division of Neurology, Institute of Neurological Sciences, Tottori University, Faculty of Medicine
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Object: The potential effects of branched-chain ammo acids (BCAAs) on spinocerebellar degeneration (SCD) were explored in eleven patients. Methods: The patients received 200 ml of BCAA-rich solution, 2 mg of thyrotropin-releasing hormone (TRH; protirelin), or a placebo daily for 7 days each in a random order. An SCD score was used to quantify the severity of symptoms. Patients: Eleven patients with SCD (7 male, 4 female; mean age 60±11; mean disease duration 5.5 years) participated in this study. Results: The mean SCD score of the eleven patients improved significantly by the BCAA treatment compared with the baseline. The conditions of five of the eleven patients (45%) were clearly improved by the BCAA treatment. All of the responders manifested predominantly cerebellar symptoms, but no prominent parkinsonian symptoms. Two patients with marked rigidity and akinesia did not respond to the treatment. Conclusion: We concluded that BCAAs do have a beneficial effect on functional improvement in patients with SCD, and that further large scale studies are needed.<br>(Internal Medicine 38: 401-406, 1999)
収録刊行物
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- Internal Medicine
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Internal Medicine 38 (5), 401-406, 1999
一般社団法人 日本内科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679843257728
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- NII論文ID
- 10005528763
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- NII書誌ID
- AA10827774
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- COI
- 1:CAS:528:DyaK1MXmtVSlurs%3D
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- ISSN
- 13497235
- 09182918
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- NDL書誌ID
- 4761803
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- PubMed
- 10397076
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可