ＩＬ‐８の増加をみた糖尿病性ケトアシドーシス　　白血球増加とＩＬ‐８の関連

• 清野 弘明

  太田西ノ内病院糖尿病センター内科

• 刈田 明代

  太田西ノ内病院糖尿病センター内科

• 荒若 信子

  太田西ノ内病院糖尿病センター内科

• 山崎 俊朗

  太田西ノ内病院糖尿病センター内科

• 菊池 宏明

  太田西ノ内病院糖尿病センター内科

• 阿部 隆三

  太田西ノ内病院糖尿病センター内科

書誌事項

タイトル別名

• Interleukin-8 may Play a Role in Leukocytosis with Diabetic Ketoacidosis.
• 白血球増加とIL-8の関連

抄録

We have found leukocytosis in serum of two patients with diabetic ketoasidosis without compli cationby definite infection. In case 1, a 17-year-old boy was admitted to our hospital because of diabetic ketoacidosis. Laboratory findings revealed a plasma glucose level of 1, 053mg/dl, a pH of 7.125 and a WBC count of 16, 900/mm³. In Case 2, a 29-year-old man was admitted because of diabetic ketoacidosis, and laboratory findings revealed a plasma glucose level of 739mg/dl, a pH of 7.190 and a WBC count of 16, 200/mm³. In both cases, the CRP level was below 0.5.<BR>We measured the serum levels of cytokines IL-8, IL-1βand GM-CSF in these two cases by ELISA. Only IL-8 was detected in the serum of both patients. The levels were 546pg/ml in case 1 and 64pg/ml in case 2. After recovery from diabetic ketoacidosis and normalization of plasma glucose levels, the IL-8 level in these two patients was below the detection limit of 20pg/ml.<BR>Serum IL-8 in patients with diabetic ketoacidosis may induce leukocytosis. According to our knowledge, this is the first report of detection of IL-8 in the serum of patients with diabetic ketoacidosis.

収録刊行物

• 糖尿病

  糖尿病 41 (8), 699-704, 1998

  一般社団法人 日本糖尿病学会

キーワード

• 糖尿病性ケトアシドーシス
• 白血球増加
• インターロイキン-8

詳細情報

• CRID: 1390282679882956928
• NII論文ID: 10005567411
• NII書誌ID: AN00166576
• DOI: 10.11213/tonyobyo1958.41.699
• ISSN: 1881588X
• ISSN: 0021437X
• Web Site: https://search.jamas.or.jp/link/ui/1999038543
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可